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MicroRNA-140 is highly expressed in cartilage and is a master regulator of chondrocytes (the cells responsible for cartilage formation).

A clinical review published on PubMed demonstrates that miR-140 heavily dictates how sensitive cancer cells are to chemotherapy drugs like doxorubicin, cisplatin, and temozolomide. Up-regulating its expression can actively enhance the efficacy of these treatments. 140 РђРЅРѕРЅСЃ

Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix. MicroRNA-140 is highly expressed in cartilage and is

It is necessary for normal endochondral ossification, the process by which the growing skeleton is formed. Mice lacking this gene often exhibit dwarfism and craniofacial abnormalities due to impaired chondrocyte proliferation. 140 РђРЅРѕРЅСЃ