[s5e22] What A Difference A Day Makes May 2026

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances.

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts [S5E22] What a Difference a Day Makes

: As a wedding gift, Derek gives Meredith her first solo surgery—a successful colon surgery overseen by Richard Webber. : Creator Shonda Rhimes noted that Denny's appearance