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The show's success led to international distribution and several remakes. An American adaptation, also titled Doc (2025) , premiered on Fox in January 2025, and a Turkish version was also produced.

In 2013, Piccioni suffered a car accident that caused him to forget the last 12 years of his life.

He has no memory of the deaths of loved ones, the breakdown of his marriage, or the distance between him and his children. The Real-Life Inspiration Doc.Nelle.Tue.Mani.S01.iTALiAN.DSNP.WEBRip.XviD...

The series is uniquely grounded in reality. It is inspired by the true story of , the former chief of the emergency room at hospitals in Lodi and Codogno.

He is no longer the respected head of medicine; he must start over as a "trainee" alongside younger residents. The show's success led to international distribution and

When he wakes up, he finds himself in a world he doesn't recognize:

Doc – Nelle tue mani follows the story of , a brilliant but cold and detached Head of Internal Medicine at the fictional Policlinico Ambrosiano in Milan. Following a traumatic brain injury—caused by being shot in the head by the grieving father of a deceased patient—Fanti survives but loses all memory of the previous twelve years of his life. He has no memory of the deaths of

It stars Luca Argentero as Dr. Fanti, whose performance has been widely praised for capturing the character's transition from an arrogant surgeon to a compassionate healer.