The narrative picks up moments after the first game's conclusion. Having defeated Lord Von Prong, DeathSpank learns the secret of the villain’s corruption: the , one of six mystical thongs forged to grant virtue but which instead corrupt their wearers. The hero embarks on a mission to collect and destroy the remaining garments, which have fallen into the hands of distorted "folk heroes": The Thong of Compassion : Possessed by an evil nun. The Thong of Cuisine : Worn by a famous television chef.
: For the first time, DeathSpank can pilot a pirate ship to explore an ocean filled with islands. Questing and Progression
: As players strike enemies, they fill a "Justice Meter," which can be unleashed for devastating special attacks with specific "Justice Weapons".