Steinberg’s most significant scientific contribution was the development of the . Over three decades, he and his colleagues published over 100 manuscripts providing evidence that oxidized LDL cholesterol drives the development of atherosclerosis (the buildup of fats and cholesterol in artery walls).
: This hypothesis remains a central pillar of cardiovascular medicine, having inspired over 8,000 follow-up papers from laboratories worldwide. Clinical Leadership and the Cholesterol Trials Daniel Steinberg - Michigan
: His research showed that oxidized LDL is proinflammatory and immunogenic, explaining the inflammatory nature of arterial lesions. having inspired over 8