Bleeder's Disease -

In the 19th and 20th centuries, it was famously known as the "Royal Disease." Queen Victoria was a carrier and passed the gene to various royal houses across Europe, including the ruling families of Spain, Germany, and Russia. The most famous case was Alexei Nikolaevich, the Tsar’s son, whose condition led the family to seek help from the mystic Rasputin, indirectly impacting the Russian Revolution. Types and Severity

Since females have two X chromosomes (XX), a healthy gene on one can usually compensate for a faulty one on the other. The Royal Connection bleeder's disease

Regular infusions of replacement clotting factors allow patients to lead near-normal lives. In the 19th and 20th centuries, it was

Also known as "Christmas Disease" (named after the first patient diagnosed with it), caused by a lack of Factor IX . In the 19th and 20th centuries

Hemophilia is almost always inherited and is "X-linked." This means the gene responsible for the condition sits on the X chromosome.