: Azoles inhibit the cytochrome P450-dependent enzyme lanosterol

: This binding creates physical pores or channels in the membrane. Small essential molecules and cellular organelles leak out of these pores, causing cell death. Common Examples : Amphotericin B, nystatin , and natamycin. 3. Echinocandins

-demethylase. This enzyme is required to synthesize ergosterol, a vital component of the fungal cell membrane.